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Authors concluded that, in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and subsequently DNA becomes methylated and inaccessible resulting in transcriptional silencing thus demonstrating interplay between histone reprogramming and promoter region methylation (Okino et al., 2007)

During the week before the experiments began, all mice were housed under conventional conditions and fed a standard diet and water ad libitum at the animal facility (Research Resource Facility)